DNA Methylation of the Aryl Hydrocarbon Receptor Repressor Associations with Cigarette Smoking and Subclinical Atherosclerosis Running title: Reynolds et al.; AHRR Methylation Associations with Atherosclerosis
نویسندگان
چکیده
Dept of Epidemiology & Prevention, Division of Public Health Sciences, Ctr for Human Genomics, Depts of Internal Medicine & Gerontology and Geriatric Medicine, J. Paul Sticht Ctr on Aging, Wake Forest School of Medicine, Winston-Salem; National Inst of Environmental Health Sciences, NIH, Research Triangle Park, NC; New York Academy of Medicine, New York, NY; 4 Depts of Environmental & Occupational Health Sciences, Medicine & Epidemiology, Univ of Washington, Seattle, WA; Depts of Medicine & Epidemiology, Columbia Univ Medical Center, New York, NY; Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN; Center for Public Health Genomics, Univ of Virginia, Charlottesville, VA; Human Genetics Ctr, School of Public Health, Univ of Texas Health Science Center at Houston, Houston, TX; Univ of Wisconsin School of Medicine & Public Health, Madison, WI; Molecular Biology, Nijmegen Centre for Molecular Life Sciences (NCMLS), Nijmegen, Netherlands; Depts of Pathology & Cardiology, Johns Hopkins Univ, Baltimore, MD; Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA *contributed equally
منابع مشابه
DNA Methylation of the Aryl Hydrocarbon Receptor Repressor Associations With Cigarette Smoking and Subclinical Atherosclerosis.
BACKGROUND Tobacco smoke contains numerous agonists of the aryl hydrocarbon receptor (AhR) pathway, and activation of the AhR pathway was shown to promote atherosclerosis in mice. Intriguingly, cigarette smoking is most strongly and robustly associated with DNA modifications to an AhR pathway gene, the AhR repressor (AHRR). We hypothesized that altered AHRR methylation in monocytes, a cell type...
متن کاملAryl Hydrocarbon Receptor Repressor Methylation: A Link Between Smoking and Atherosclerosis.
C igarette smoking remains a worldwide health epidemic. In the United States, despite the well-established risks, cigarette smoking remains the leading cause of preventable disease and death accounting for >480 000 deaths annually, with 1 in every 3 of such deaths related to cardiovascular diseases (CVD). 1 For every patient who dies because of smoking, at least 30 people live with a serious sm...
متن کاملReversion of AHRR Demethylation Is a Quantitative Biomarker of Smoking Cessation
Smoking is the largest preventable cause of morbidity and mortality in the world. Although there are effective pharmacologic and behavioral treatments for smoking cessation, our inability to objectively quantify smokers' progress in decreasing smoking has been a barrier to both clinical and research efforts. In prior work, we and others have shown that DNA methylation at cg05575921, a CpG resid...
متن کاملAHRR (cg05575921) hypomethylation marks smoking behaviour, morbidity and mortality
RATIONALE AND OBJECTIVES Self-reported smoking underestimates disease risk. Smoking affects DNA methylation, in particular the cg05575921 site in the aryl hydrocarbon receptor repressor (AHRR) gene. We tested the hypothesis that AHRR cg05575921 hypomethylation is associated with risk of smoking-related morbidity and mortality. METHODS From the Copenhagen City Heart Study representing the Dani...
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A single cytosine-guanine dinucleotide (CpG) site within coagulation factor II (thrombin) receptor-like 3 (F2RL3) was recently found to be hypomethylated in peripheral blood genomic DNA from smokers compared with former and non-smokers. We performed two epigenome-wide association studies (EWAS) nested in a prospective healthy cohort using the Illumina 450K Methylation Beadchip. The two populati...
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